Abstract Background Canine hemangiosarcoma (HSA) is a malignant tumor with poor long-term prognosis due to development of metastasis despite aggressive treatment. The phosphatidyl-inositol-3 kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is involved in its endothelial pathologies; however. it remains unknown how this pathway plays a role in canine HSA. Here. https://www.lockdownsecuritycanada.shop/product-category/fuse/