Sickle cell disease (SCD) is a genetic blood disorder affecting red blood cells. with high morbidity and mortality rates. The United Nations has recognized SCD as a global public health concern. and the World Health Organization (WHO) recommends that 50% of member states will have established SCD control programs by 2020 (World Health Organization. https://parisnaturalfoodes.shop/product-category/hyaluronic-acid-night-creme/