Abstract Background Gout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of this study was to investigate the mechanisms of gene expression regulation in gout disease and elucidate its pathogenesis. Methods The study integrated gout genome-wide association study (GWAS) data. single-cell transcriptomics (scRNA-seq). https://parisnaturalfoodes.shop/product-category/cheesecloth/