Abstract There is accumulating evidence of endothelial dysfunction. muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In this paper we deduce the pathomechanisms resulting in central nervous pathology and the myriad of neurocognitive symptoms. We outline tentative mechanisms of impaired cerebral blood flow. https://lecoureures.shop/product-category/ski-de-fond-skis-a-roulettes/