The efficacy of 4 g 5-aminosalicylic acid (5-ASA. mesalamine) enemas was assessed in 666 patients with distal ulcerative colitis. Patients were enrolled in an open-label compassionate use program. One 4 g 5-ASA enema was administered each night for a period of four weeks and the disease activity index was assessed at baseline and on days 14 and 28. https://www.roneverhart.com/Grace-Design-M801-MK2-High-Fidelity-p15168/